Aim: Because the pathogenic microbes can be transmitted through blood and saliva, therefore the dental personal are more likely to be exposed to infectious diseases than other people. Transmission of INFECTION from a patient to another one is high probability. Through dental treatment, the importance of the INFECTION control would be more lighted when we know it is not impossible to define all the patients with infectious diseases. Therefore apply the standard methods of INFECTION control is very necessary. In this study we intended to examine the methods of prevention and INFECTION control in Tehran general dental offices.Method & Material: This investigation is descriptive which is CROSS sectional. Samples in every class were selected by systemic random sampling included general dental offices. The study was done in winter 2001. Information gathered by two ways observation and questionnaire, observing the dentist treating the patient personal protection such as gloves, masks, glasses, ... and decoration of office. Questionnaire was included 50 question items about vaccination, personal protection; ways of sterilization, disINFECTION the surfaces, ways of discarding of contaminated wastes and INFECTION control in radiology.Results: The most important obtained results are a following:- vaccinated against hepatitis B: 97.5% dentists - 56.41% personal in the offices.- used 75.4% gloves, 61% mask and 53% protective glass by dentist.- 18.7% of dentists sterilized hand pieces for every patient, 42.3% sterilized their burs by heat.- 87.7% of dentists did not disinfect radiology set.- 49.5% of dentists disinfected the orders delivered by the laboratory before apply them to patients.Conclusion: The obtained results show the applied methods in general dental offices in Tehran are very far from the standard recommendation be ADA, CDC in views quantity and quality. Therefore it is very necessary to bring up the- knowledge about the principle of INFECTION control and to make available the essential equipment to reduce the seriously risk of CROSS INFECTION spread in our society.